Singh, K., R. A. Erdman, K. M. Swanson, A. J. Molenaar, N. J. Maqbool, T. T., J. Arias, E. Quinn-Walsh, and K. Stelwagen. 2009. Epigenetic Regulation of Milk Production in Dairy Cows. J. Mammary Gland Biol. Neoplasia. 14 (In Press).
Vyas, D., and R. A. Erdman. 2009. Meta-analysis of milk protein yield responses to lysine and methionine supplementation. J Dairy Sci. 92:5011-5018. Read Article
Kadegowda A.K.G., M. Bionaz, L.S. Piperova, R. A. Erdman, and J. J. Loor. 2009 Peroxisome proliferator-activated receptor-gamma activation and long-chain fatty acids alter lipogenic gene networks in bovine mammary epithelial cells to various extents J. Dairy Sci. 92: 4276-4289. Read Article
Kadegowda. A. K. G., M. Bionaz, B. Thering, L. S. Piperova, R. A. Erdman, and J.J. Loor. 2009. Identification of Internal Controls for Quantitative PCR in Mammary Tissue of Lactating Cows Receiving Lipid Supplements J. Dairy Sci. 92:2007-2019. Read Article
Kadegowda, A.K.G., L.S. Piperova, P. Delmonte, and R.A. Erdman. 2008. Abomasal infusion of butterfat increases milk fat in lactating dairy cows. J. Dairy Sci. 91:2370-2379. Read Article
Kadegowda, A.K.G., L.S. Piperova, and R.A. Erdman. 2008. Principal component and multivariate analysis of milk long-chain fatty acid composition during diet-induced milk fat depression. J. Dairy Sci. 91:749-759. Read Article
Our laboratory studies nutrient-gene interactions that influence milk fat and protein synthesis in the dairy cow. Our current work focuses on the influence of short and medium chain fatty acids on milk fat synthesis. We have demonstrated that milk fat synthesis increases when supplemental short and medium chain fatty are provided to the dairy cow and are examining their effects on the gene expression, protein abundance, and enzymatic activity of the two major enzymes involved in de novo fatty acid synthesis: fatty acid synthase (FASN) and acetyl-CoA carboxylase (ACC). We use a variety of in vivo and in vitro models including cell culture, the lactating mouse, and lactating dairy cows along with molecular, cellular, and biochemical techniques to study nutritional influences on: