Moyes, K.M., J.K. Drackley, M. Bionaz, D.E. Morin, S. Rodriguez-Zas, R.E. Everts, H.A. Lewin, and J.J. Loor. 2009. Gene network and pathway analysis of bovine mammary tissue challenged with Streptococcus uberis reveal induction of cell proliferation and inhibition of PPAR-gamma signaling as potential mechanisms for the negative relationship between immune response and lipid metabolism. BMC Genomics. 10:542.
Moyes, K.M., J.K. Drackley, J.L. Salak-Johnson, D.E. Morin, J.C. Hope, and J.J. Loor. 2009. Dietary-induced negative energy balance has minimal effects on innate immunity during a Streptococcus uberis mastitis challenge in dairy cows during mid-lactation. J. Dairy Sci. 92:4301-4316.
Moyes, K.M., T. Larsen, N.C. Friggens, J.K. Drackley, and K.L. Ingvartsen. 2009. Identification of potential markers in blood for the development of sub-clinical and clinical mastitis in dairy cattle at parturition and during early lactation. J. Dairy Sci. 92:5419-5428.
Moyes, K.M., N.C. Friggens, and K.L. Ingvartsen. 2010. Nutritional strategies to combat physiological imbalance of dairy cows during early lactation: The effect of changes in dietary protein to starch-ratios. Acta Agriculturae Scandinavica A. 60:166-174.
Loor, J.J., K.M. Moyes, and M. Bionaz. 2011. Functional genomic adaptions to mastitis-causing pathogens: the mammary gland and beyond. J. Mammary Gland Biol. & Neoplasia. 16:305-322.
K.M. Moyes, D.E. Graugnard, M.J. Khan, M. Mukesh, M. Bionaz, and J.J. Loor. 2012. Immunometabolic genes are altered in response to prepartal energy intake and postpartal intramammary inflammatory challenge in blood neutrophils postpartum. J. Dairy Sci. 95:1749-1758.
Graugnard, D.E., M. Bionaz, E. Trevisi, M. Mukesh, M. Ordonez, K.M. Moyes, J.L. Salak-Johnson, R.L. Wallace, J.K. Drackley, G. Bertoni, and J.J. Loor. 2012. Blood immunometabolic indices and polymorphonuclear leukocyte function in peripartal dairy cows are altered by level of dietary energy prepartum. J. Dairy Sci. 95:1749-1758.
Bjerre-Harpøth, V., N.C. Friggens, V.M. Thorup, T. Larsen, B.M. Damgaard, K.L. Ingvartsen, and K.M. Moyes. 2012. Metabolic and production profiles of dairy cows in response to decreased nutrient density to increase physiological imbalance at different stages of lactation. J. Dairy Sci. 95:2362-2380.
Ingvartsen, K.L. and K.M. Moyes. 2013. Nutrition, immune function and health of dairy cattle. Animal. 7(Suppl 1):112-122.
Moyes, K.M., E. Bendixen, M.S. Codrea, and K.L. Ingvartsen. 2013. Identification of hepatic biomarkers for physiological imbalance of dairy cows in early and mid-lactation using proteomic technology. J. Dairy Sci. 96:3599-3610.
Moyes, K.M., T. Larsen, and K.L. Ingvartsen. 2013. Generation of an index for physiological imbalance and its use as a predictor of disease in dairy cows during early lactation. J. Dairy Sci. 96:2161-2170. (One of top 25 most downloaded for 2013)
Graugnard, D.E., K.M. Moyes, E. Trevisi, M.J. Khan, D. Keisler, J.K. Drackley, G. Bertoni, and J.J. Loor. 2013. Liver lipid content and inflammometabolic indices in peripartal dairy cows are altered in response to prepartal energy intake and postpartal intramammary inflammatory challenge. J. Dairy Sci. 95:1749-1758.
K.M. Moyes, D.E. Graugnard, M.J. Khan, M. Mukesh, and J.J. Loor. 2014. Immunometabolic gene networks in blood neutrophils postpartum are altered in response to prepartal energy intake and postpartal intramammary inflammatory challenge. J. Dairy Sci. 97:2165-2177.
K.M. Moyes, L. Ma, T. McCoy and R. Peters. 2014. A survey regarding the interest and concerns associated with transitioning from conventional to automated (robotic) milking systems for managers of small to medium-sized dairy farms. The Professional Animal Scientist. Accepted.
T. Larsen and K.M. Moyes. 2014. Are free glucose and glucose-6-phosphate in milk indicators of specific physiological states in the cow? Animal. Accepted.
K.M. Moyes. 2014. Nutrient partitioning could help our fresh cows. Hoard’s Dairyman. W.D. Hoard & Sons Co., Feb. 25, pp.132.
1. Nutrition and immunology
Our lab currently works in the area of nutritional immunology with a focus on dairy cattle.
Our research primarily focuses on reducing the incidence and severity of diseases and disorders by improving dairy health and well-being through the transition period. We investigate the immunometabolic response during inflammation via genomics, proteomics and metabolomics in various tissues and immune cells. Characterizing host responses and identifying the mechanistic links between the immune system and metabolism during an intramammary infection at different physiological and nutritional states will provide unique insight into mechanisms controlling immune response and nutrient partitioning in different tissue types. Knowledge gained from this research is essential to the development of future treatment strategies and genetic selection programs that will help minimize susceptibility, severity and/or duration of mastitis and improve overall health and milk quality.
2. Evaluating the use of automatic milking systems (AMS) in the Mid-Atlantic region
Our current objective is to use case study farms to estimate and quantify the economic impacts and animal health/productivity and lifestyle changes for small-to medium sized dairy farms regarding the transition from conventional to AMS in the Mid-Atlantic region. In turn, the information provided will help farmers determine whether AMS is economical and personally beneficial for their farm thereby helping sustain the dairy industry in the Mid-Atlantic region.
3. Biomarkers for physiological imbalance
In collaboration with Danish scientists at Aarhus University, Tjele, Denmark, our objective to identify and evaluate the use of new biomarkers in blood and milk for use as biosensors for an in-line monitoring system that gives the farmer a real-time relating to risk and development of physiological imbalance for cows during lactation. Using potent research tools in genomics and metabolomics, we currently identify potential markers in milk that form the bases for the first generation of biomodels and standard operations procedures that proactively help prevent physiological imbalance and improve dairy cow welfare and productivity while improving the farmer’s surveillance, risk management and subsequently economic outcome
4. Characterization of nutrients and immunoglobulins in anthropoid primate milks
In collaboration with Dr. Mike Powers, Smithsonian Institution, our specific aims are to 1) identify the nutrient and immunoglobulin profiles in mammary secretions (milk) from gorillas and orangutans throughout lactation; 2) investigate the relationships among these milk constituents; 3) compare the results from the two great ape species to results from a more limited set of monkey milks to examine differences between monkeys and apes; and 4) compare these patterns of nutrients and immunoglobulins to published data on human milk to assess the evolutionary changes in milk nutrients and immunoglobulins after the divergence of the African ape and human lineages.
Yang Qu (M.S. Oregon State University
Dr. Miriam Garcia Orellana (Ph.D. University of Florida)