Research - Developmental Biology/Embryonic Patterning
The Taneyhill lab studies the vertebrate neural crest, a transient population of migratory cells that ultimately differentiate to become a wide range of structures, including the peripheral nervous system, skin pigment cells, portions of the heart, and the craniofacial skeleton. Consequently, many human congenital and hereditary malformations, diseases and cancers result from aberrant neural crest development. Our lab uses molecular, cellular, and biochemical techniques to study neural crest formation in the chicken embryo to better understand overall embryonic patterning and animal growth and development.
- Neural crest
- Embryonic patterning/development
- Cell migration and EMT
- Cancer/metastasis
Teaching
- ANSC 497: Animal Biotechnology Recombinant DNA Laboratory
- ANSC 688G: Special Topics - Animal Biotechnology Recombinant DNA Laboratory
- Coming in Fall 2010 - Developmental Biology
Awards and Honors
- University of Maryland Searle Scholar Program nominee, 2009
- University of Maryland Packard Foundation nominee, 2009
- University of Maryland Pew Scholarship nominee, 2008
- Research findings published on the cover of Developmental Biology, December 2007
- Women in Science Scholar (Elsevier Foundation), 2007
- NIH Pathway to Independence Award (K99/R00), 2006-2011
Other Accomplishments
- Author of 11 refereed scientific papers, 3 book chapters or reviews, and 17 abstracts.
- Publications cited 358 times.
- Identified first direct, in vivo target of the embryonic transcriptional regulator Snail2 in the neural crest.
- Recipient of ~ $900,000 in total costs through competitive federal grants.
Publications
- Jhingory S, Wu, C, and Taneyhill LA. 2009. Novel insight into the function and regulation of aN-catenin by Snail2 during chick neural crest cell emigration. Under re-review at Development.
- L.A. Taneyhill 2008. To adhere, or not to adhere: The role of Cadherins in neural crest development. Cell Adhesion and Migration 2: 1-8. Read Article
- L.A. Taneyhill and Adams MS. 2008. Investigating Regulatory Factors and their DNA Binding Affinities Through Real Time Quantitative PCR (RT-QPCR) and Chromatin Immunoprecipitation (ChIP) Assays. In: Methods in Cell Biology, Avian Embryology, 2nd Edition. Eds. M Bronner-Fraser, L Wilson, PT Matsudaira. Elsevier, Inc. Read Article
- E. G. Coles, L. A. Taneyhill, and M. Bronner-Fraser. 2007. A critical role for Cadherin6B in regulating avian neural crest emigration. Dev Biol 312: 533-544. Read Article
- L. A. Taneyhill, E. G. Coles, and M. Bronner-Fraser. 2007. Snail2 directly represses cadherin6B during epithelial-to-mesenchymal transitions of the neural crest. Development 134: 1481-1490. Read Article
- L. A. Taneyhill and M. Bronner-Fraser. 2005. Recycling signals in the neural crest. J Biol 4: 10.1-10.4. Read Article
- L. A. Taneyhill and M. Bronner-Fraser. 2005. Dynamic alterations in gene expression after Wnt-mediated induction of avian neural crest. Mol Biol Cell 16: 5283-5293. Read Article
- L. A. Taneyhill. 2005. Understanding embryonic development: from screens to genes. Genome Biol 6: 359-361. Read Article
- L. A. Taneyhill and D. Pennica. 2004. Identification of Wnt responsive genes using a murine mammary epithelial cell line model system. BMC Dev Biol 4: 6. Read Article
Grants
| Project | Funding Source | Amount |
| Functional Roles of Wnt and Snail2 Target Genes | Elsevier Scholars (Women in Science) Foundation | $10,000 |
| Functional Roles of Wnt and Snail2 Target Genes in Neural Crest Development | NIH Pathway to Independence Award (R00), NICHD | $747,000 |
| Administrative Supplement for Summer Student Research (HD055034), Competitive, Functional Roles of Wnt and Snail2 Target Genes in the Neural Crest. | NIH Pathway to Independence Award (R00), NICHD | $8,640 |
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