Research - Cell Biology and Genetics of Micronutrient Metabolism

Cell Biology and Genetics of Micronutrient Metabolism see website for more details

Teaching

• ANSC327/ANSC627: Molecular and Quantitative Animal Genetics

Publications

Representative Publications

• Rajagopal A, Rao AU, Amigo J, Tian M, Upadhyay SK, Hall C, Uhm S, Mathew MK, Fleming MD, Paw BH, Krause M and Hamza I. Heme homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature 2008; 453: 1127-1131 (Epub Apr 16, 2008) Download PDF
  Highlighted by United Press International, Worms help in iron deficiency research
• Nass R and Hamza I. The Nematode C. elegans as an Animal Model to Explore Toxicology In Vivo: Solid and Axenic Growth Culture Conditions and Compound Exposure Parameters. In: Current Protocols in Toxicology Eds. Bus, JS, Costa LG, Hodgson E, Lawrence DA and Reed DJ. John Wiley & Sons, Inc., 2007; Unit 1.9 1.9.1-1.9.17. Download PDF.
• Hamza I. Intracellular Trafficking of Porphyrins. ACS Chem. Biol. 2006;1: 627–629 Download PDF
• Held MR, Bungiro RD, Harrison LM, Hamza I and Cappello M. Dietary iron content mediates hookworm pathogenesis in vivo. Infect Immun. 2006;74:289-295 Download PDF.
  Highlighted in Science magazine
• Rao A, Carta L, Lesuisse E and Hamza I. Lack of Heme Synthesis in a Free-Living Eukaryote. Proc Natl Acad Sci. 2005; 102:4270-4275 Download PDF (Supporting Data)
• Hamza I, Prohaska JR and Gitlin. JD. Essential Role for Atox1 in the Copper-Mediated Intracellular Trafficking of the Menkes ATPase. Proc Natl Acad Sci. 2003; 100:1215-1220 Download PDF.
• Hamza I and Gitlin JD. Copper chaperones for cytochrome c oxidase and human disease. J Bioenerg Biomembr. 2002; 34:381-388 Download PDF.
• Hamza I and Gitlin JD. Hepatic Copper Transport. In: Molecular Pathogenesis of Cholestasis Ed. Trauner, M and Jansen P. Landes Bioscience, Austin, Texas 2002.
• Hamza I and Gitlin JD. Copper-transporting ATPases. In: The Encyclopedia of Molecular Medicine Ed. Creighton T. New York, John Wiley & Sons, 2002; 904-906.
• Hamza I, Faisst A, Prohaska JR, Chen J, Gruss P and Gitlin. JD. The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis. Proc Natl Acad Sci. 2001; 98: 6848-6852 Download PDF
  Editorial in PNAS by Andrews NC
  Highlighted in BBC World News
• Hamza I and Gitlin JD. Copper metabolism and the Liver. In: The Liver: Biology and Pathobiology. I Arias, Boyer, F Chisari, N Fausto, D Schachter and D Shafritz (eds) Williams and Wilkins, 2001; 331-343.
• Hamza I, Klomp LWJ, Gaedigk R, White RA and Gitlin JD. Structure, expression and chromosomal localization of the mouse Atox1 gene. Genomics 2000; 63:294-297 Download PDF.
• Hamza I, Qi Z, King ND and O'Brian MR. Fur-independent regulation of iron metabolism by Irr in Bradyrhizobium japonicum. Microbiology 2000; 146:669-676 Download PDF.
• Hamza I, Schaefer M, Klomp LWJ and Gitlin JD. Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. Proc Natl Acad Sci. 1999; 96:13363-13368 Download PDF.
• Qi Z, Hamza I and O'Brian MR. Heme is an effector molecule for iron-dependent degradation of the bacterial iron response regulator (Irr) protein. Proc Natl Acad Sci. 1999; 96:13056-13061 Download PDF.
• Hamza I, Hassett R and O'Brian MR. Identification of a functional fur gene in Bradyrhizobium japonicum. J Bacteriol. 1999; 181:5843-5846 Download PDF.
• Hamza I, Chauhan S, Hassett R and O'Brian MR. The bacterial Irr protein is required for coordination of heme biosynthesis with iron availability. J Biol Chem. 1998; 273:21669-21674 Download PDF.